Aa. Chepurnov et al., STUDY OF IMMUNOBIOLOGICAL PROPERTIES OF E BOLA-VIRUS VP24 PROTEIN EXPRESSED BY RECOMBINANT VACCINIA VIRUS, Voprosy virusologii, 42(3), 1997, pp. 115-120
Immunological and biochemical parameters were studied in guinea pigs i
mmunized with recombinant vaccinia virus containing full-sized gene of
Ebola virus vp24 protein and then infected with virulent strain of Eb
ola virus. The majority of the studied parameters changed similarly in
guinea pigs immunized with recombinant vaccinia virus and control gui
nea pigs inoculated with vaccinia virus both before and after challeng
e with Ebola virus. However, in animals immunized with recombinant vac
cinia virus producing vp24 some biochemical parameters, the mean life
span after challenge with Ebola virus, the level of antibodies to the
virus and the phagocytic activity of neutrophils indicated the develop
ment of immunological processes other than in controls, namely, the de
velopment of immune response to vp24. Although these processes did not
eventually lead to the survival of animals, they prolonged the mean l
ife span and resulted in the production of anti-Ebola antibodies, thou
gh the level thereof was low. These data demonstrate that recombinant
vaccines against Ebola fever are a promising trend of research.