CHANGES IN SOME HEMOSTASIS PARAMETERS IN RABBITS INOCULATED WITH EBOLA-VIRUS

Changes in some parameters of hemostasis in rabbits insusceptible to E bola virus (EV) in various periods after reinoculations with live and inactivated virus are described. Challenge with both control protein a nd live and inactivated EV leads to imbalance in the hemostasis system , which is compensated for in the course of follow-up and does not res ult in clinically manifest disorders of blood clotting. However, the m echanisms of development of the hemostasis imbalance caused by the con trol protein and virus preparations were different. In the former case no fibrinogen degradation products were detected in the blood serum, whereas in the latter they appeared in the serum after each reinoculat ion of the virus. This indicates a peculiar effect of EV on hemostasis .