A prospective crossover clinical study evaluated solute removal and biocomp
atibility of a tailored, hydrophobic-hydrophilic microdomain structure prod
uced from a blend of polyamide, polyarylethersulfone, and polyvinylpyrrolid
one (Polyflux) compared with Fresenius Polysulfone in dialyzers of similar
surface area. The clearance of small molecules (urea, creatinine, and phosp
hate) for both membranes was comparable. plasma levels of beta (2) microglo
bulin were reduced at the end of treatment with both membranes (49.8% of pr
etreatment values for Polyflux; 45.9%, Fresenius Polysulfone) and was assoc
iated with the recovery of 207 +/- 84 mg of beta (2) microglobulin from the
dialyzing fluid for Polyflux compared with 147 +/- 29 for Fresenius Polysu
lfone (p = 0.12). The dialyzing fluid also contained 7,758 mg of protein wh
en using Polyflux compared with 7,793 mg using Fresenius Potysulfone (stand
ard error of difference for any pair was 511 mg). No albumin was present in
the dialysis fluid for either membrane. Neutropenia, platelet adhesion to
the membrane, and complement activation characterized by C3a, C5a, and SC5b
-9 generation were slight and independent of membrane type. Membrane thromb
us generating potential measured by thrombin:antithrombin III were also sim
ilar. These results indicate that the tailored, hydrophobic-hydrophilic mic
rodomain structure of the membrane results in a favorable biocompatibility
profile and clinically acceptable solute removal similar to the widely used
Fresenius PolysuIfone membrane.