Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34

Here we identified the human serine/threonine kinase HIPK2 as a novel membe r of the DYRK kinase subfamily. Alignment of several DYRK family proteins i ncluding the kinases minibrain, MJAK, PKY, the Dictyostelium kinase YakA an d Saccharomyces YAK1 allowed the identification of several evolutionary con served DYRK consensus motifs within the kinase domain. A lysine residue con served between all DYRK kinase family members was found to be essential for the kinase function of HIPK2. Human HIPK2 was mapped to chromosome 7q32-q3 4 and murine HIPK2 to chromosome 6B, the homologue to human chromosome 7. ( C) 2000 Societe francaise de biochimie et biologie moleculaire / Editions s cientifiques et medicales Elsevier SAS.