Rat small intestine muscle relaxation alkaloids from Orixa japonica leaves

Authors
Funayama, S Tanaka, R Kumekawa, Y Noshita, T Mori, T Kashiwagura, T Murata, K
Citation
S. Funayama et al., Rat small intestine muscle relaxation alkaloids from Orixa japonica leaves, BIOL PHAR B, 24(1), 2001, pp. 100-102
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
24
Issue
1
Year of publication
2001
Pages
100 - 102
Database
ISI
SICI code
0918-6158(200101)24:1<100:RSIMRA>2.0.ZU;2-W
Abstract
Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from th e methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle relaxant papaverine (4). This is also the first report of the isolation of eduline (2) from O. japonica.