New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris

Five new constituents including a flavonoid, artemisidin A (1), and four co umarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial par t of Artemisia capillaris. The structures of these compounds were determine d from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18, 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggre gation activity and three compounds (10, 17, and 51) demonstrated significa nt activity against HIV replication in H9 lymphocytic cells. (C) 2000 Elsev ier Science Ltd. All rights reserved.