The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia

Authors
Whitman, SP Strout, MP Marcucci, G Freud, AG Culley, LL Zeleznik-Le, NJ Mrozek, K Theil, KS Kees, UR Bloomfield, CD Caligiuri, MA
Citation
Sp. Whitman et al., The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia, CANCER RES, 61(1), 2001, pp. 59-63
Citations number
22
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER RESEARCH
ISSN journal
00085472 → ACNP
Volume
61
Issue
1
Year of publication
2001
Pages
59 - 63
Database
ISI
SICI code
0008-5472(20010101)61:1<59:TPNDOT>2.0.ZU;2-#
Abstract
A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia,without structural cytogene tic abnormalities at 11q23 and 9p22. A duplicated portion of MLL is interru pted by the insertion of a region of 9p22 that includes the 3'-end of the A F9 gene. The PNTD encodes: (a) a PNTD transcript; (b) a partial tandem dupl ication of MLL; and (c) a chimeric transcript fusing MLL to the 3'-end of A F9, mimicking the t(9;11)(p22;q23) and expressed 1024-fold higher than the other two. The MLL PNTD, therefore, contributes toward leukemogenesis throu gh simultaneous production of fusion transcripts that are otherwise encoded by three distinct genetic defects.