Structure-activity relationships for a collection of structurally diverse inhibitors of purine nucleoside phosphorylase

Citation
Ad. Andricopulo et Ra. Yunes, Structure-activity relationships for a collection of structurally diverse inhibitors of purine nucleoside phosphorylase, CHEM PHARM, 49(1), 2001, pp. 10-17
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
49
Issue
1
Year of publication
2001
Pages
10 - 17
Database
ISI
SICI code
0009-2363(200101)49:1<10:SRFACO>2.0.ZU;2-4
Abstract
Values of inhibition constants, K-i, and concentrations required for 50% in hibition, IC50, for a collection of structurally diverse competitive inhibi tors of calf spleen purine nucleoside phosphorylase have been determined em ploying inosine as substrate. These values have been employed to create pre dictive quantitative structure-activity relationships (QSAR) which link str ucture to values of K-i and IC50. These QSAR models have substantial power to predict values and the associated uncertainties for K-i and IC50 for unk nown, structurally diverse inhibitors of purine nucleoside phosphorylase.