Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesisof the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

Authors
Benedetti, F Norbedo, S
Citation
F. Benedetti et S. Norbedo, Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesisof the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir), CHEM COMMUN, (2), 2001, pp. 203-204
Citations number
15
Categorie Soggetti
Chemistry
Journal title
CHEMICAL COMMUNICATIONS
ISSN journal
13597345 → ACNP
Issue
2
Year of publication
2001
Pages
203 - 204
Database
ISI
SICI code
1359-7345(2001):2<203:ERTHDI>2.0.ZU;2-O
Abstract
A stereoselective synthesis of the diaminoalcohol core of Ritonavir illustr ates a novel approach to hydroxyethylene dipeptide isosteres, based on the regioselective reduction of amino acid-derived epoxyalcohols.