Objective: Controversy exists in relation to the nature of the acute phase
response, which is known to occur following endurance exercise. This study
was conducted to demonstrate the similarities between this response and the
response consequent to general medical and surgical conditions.
Design: This is a case series field study of serum levels of acute phase re
actants in a group of ultramarathon runners competing in a 6-day track race
.
Participants: Seven male and one female experienced ultramarathon runners.
Intervention: A track race of 6 days duration.
Main Outcome Measures: Serum iron, ferritin, transferrin, albumin, haptoglo
bin, alpha-1 antitrypsin, complement components 3 and 4, C-reactive protein
, and erythrocyte sedimentation rate, total iron binding capacity, and tran
sferrin saturation.
Results: Of the 11 acute phase reactants measured, 6 (serum iron, ferritin,
percent transferrin saturation, C-reactive protein, erythrocyte sedimentat
ion rate, and haptoglobin) responded as if an acute phase response was pres
ent; 5 (tranferrin, albumin, alpha-1 antitrypsin, and complement components
3 and 3) did not respond in such a fashion.
Conclusion: This study provides further evidence that the acute phase respo
nse consequent to exercise is analogous to that which occurs in general med
ical and surgical conditions. The previous demonstration of the presence of
the appropriate cytokines following exercise, the findings of others in re
lation to acute phase reactants not the subjects of this study, the possibi
lity that a training effect leading to attenuation of the response and the
realization that the acute phase response is not identical across a range o
f medical conditions lends weight to the above conclusion.