Analysis of cell-mediated cytotoxicity of CD18-deficient bovine neutrophils

Authors
Nagahata, H Higuchi, H Kasamatsu, M
Citation
H. Nagahata et al., Analysis of cell-mediated cytotoxicity of CD18-deficient bovine neutrophils, COMP HAEMAT, 10(2), 2000, pp. 102-104
Citations number
13
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
COMPARATIVE HAEMATOLOGY INTERNATIONAL
ISSN journal
09387714 → ACNP
Volume
10
Issue
2
Year of publication
2000
Pages
102 - 104
Database
ISI
SICI code
0938-7714(2000)10:2<102:AOCCOC>2.0.ZU;2-Z
Abstract
Killing activity (KA) and antibody-dependent cell cytotoxicity (ADCC) of ne utrophils from normal cattle and cattle with bovine leucocyte adhesion defi ciency (BLAD) were compared in order to evaluate the cytotoxicity of CD18-d eficient bovine neutrophils. The killing activity of CD18-deficient neutrop hils was significantly lowered (p<0.01) when compared to normal neutrophils , whereas ADCC activity was increased. Fc receptor for immunoglobulin G (Fc yR-IgG) mediated ADCC of neutrophils appeared to be enhanced in BLAD-neutro phils.