M. Simren et al., Abnormal propagation pattern of duodenal pressure waves in the irritable bowel syndrome (IBD), DIG DIS SCI, 45(11), 2000, pp. 2151-2161
The propagation pattern of individual pressure waves in the gastroduodenal
area in IBS is unexplored. We performed antroduodenojejunal manometry on 26
patients with IBS-13 with diarrhea predominant IBS (IBS-D) and 13 with con
stipation predominant IBS (IBSC)-and 32 healthy controls. Neuropathic-like
motor abnormalities were found in 38% of the patients with conventional man
ometric evaluation. With high-resolution analysis additional abnormalities
were observed in the majority of the patients, with increased frequency of
retrograde pressure waves postprandially in both IBS subgroups and in phase
II in IBS-D, A correlation between subjective gastrointestinal symptoms an
d the frequency of retrograde pressure waves in phase II in IBS-D was demon
strated. Motility indices and the number of long clusters were also higher
in patients compared to controls. To conclude, an abnormal propagation patt
ern of individual duodenal pressure waves in IBS patients was demonstrated
and found to be related to symptom severity in diarrhea-predominant IBS. Hi
gh-resolution analysis adds information to standard manometry.