Childhood leukemias in the Republic of Buryatia.

From 1986 to 1995 ninety-two cases of leukemia were registered in children of Buryatia: 67 cases of acute lymphoid leukemia (ALL), 19 cases of acute n on-lymphoid leukemia (ANLL) and 6 cases of chronic myelocytic leukemia (CML ). The ratio of leukemic boys to girls was uncommon: 1,0:1,23 in ALL and 1, 0:1.1 in ANLL. Mean annual morbidity for all leukemias was 3.05 +/- 0.26; f or ALL 2.22 +/- 0.16; for ANLL 0.62 +/- 0.2 and for CML 0.19 +/- 0.06 per 1 00000 children aged 0-14. In industrial districts of Ulan-Ude children got ill with leukemia 1.5 times more frequently than in districts without indus try. The relative risk was 1.95. Annual mortality per 100000 children was f or ALL 1.75 +/- 0.16, for ANLL 0.51 +/- 0.17, for CML 0.16 +/- 0.05; all le ukemias 2.44 +/- 0.18. Probability of overall survival estimated by Kaplan- Meier was studied in 57 patients given non-program treatment and 29 patient s given treatment on BFM programs. The 5-year survival in ALL was for the a bove groups 10 and 42%, respectively; 15-month survival in ANLL 7 and 50%, respectively. Better results were achieved due to conversion to BFM program s in 1993. High lethality reflected poor care for the patients, especially neglect of accompanying therapy. The importance of medicostatistic assessme nt of leukemias in children is shown.