Hepatocyte growth factor activators, inhibitors and antagonists and their implication in cancer intervention

Hepatocyte growth factor (HGF), otherwise known as scatter factor (SF), has been demonstrated over the past decade to elicit a number of functions tha t may be tumorigenic, and enhance the invasive/metastatic nature of cancer cells. Clinical studies have also demonstrated that HGF/SF, together with i ts receptor, cMET, is closely related to the disease progression and progno sis of patients with cancer. The past few years have seen the identificatio n of numerous inhibitors and antagonists to the action of HGF/SF. These fac tors have demonstrated a possible role in minimising the action of HGF/SF o n cancer cells, and may be of therapeutic value in the future. This article overviews the activators, inhibitors, and antagonists to HGF/SF and discus ses the possible implications in cancer therapy.