Model complexes of the active site in peptide deformylase: A new family ofmononuclear N2S-M(II) complexes

Authors
Chang, SC Karambelkar, VV diTargiani, RC Goldberg, DP
Citation
Sc. Chang et al., Model complexes of the active site in peptide deformylase: A new family ofmononuclear N2S-M(II) complexes, INORG CHEM, 40(2), 2001, pp. 194
Citations number
41
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
INORGANIC CHEMISTRY
ISSN journal
00201669 → ACNP
Volume
40
Issue
2
Year of publication
2001
Database
ISI
SICI code
0020-1669(20010115)40:2<194:MCOTAS>2.0.ZU;2-R
Abstract
A new tridentate N2Sthiolate ligand, PATH, has been prepared and includes a sterically hindered aliphatic thiolate donor as a cysteine mimic. PATH was employed in the synthesis of the monomeric complexes [(PATH)(MBr)-Br-[]] a nd [(PATH)(MNCS)-N-[]] (M = Zn, Co), which have been characterized by X-ray diffraction. These complexes are close structural analogues of the His(2)C ys site found in peptide deformylase.