VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase(POEMS) syndrome

Authors
Niimi, H Arimura, K Jonosono, M Hashiguchi, T Kawabata, M Osame, M Kitajima, I
Citation
H. Niimi et al., VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase(POEMS) syndrome, INTERN MED, 39(12), 2000, pp. 1101-1104
Citations number
13
Categorie Soggetti
General & Internal Medicine
Journal title
INTERNAL MEDICINE
ISSN journal
09182918 → ACNP
Volume
39
Issue
12
Year of publication
2000
Pages
1101 - 1104
Database
ISI
SICI code
0918-2918(200012)39:12<1101:VICFPH>2.0.ZU;2-O
Abstract
We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH), In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL- 1 beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports t o be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolo ne therapy, PH disappeared with a dramatic decrease in serum VEGF, Our resu lts suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome .