H. Goto et al., Simultaneous macroamylasemia and macrolipasemia in a patient with systemiclupus erythematosus in remission, INTERN MED, 39(12), 2000, pp. 1115-1118
We report the fourth case of simultaneous macroamylasemia and macrolipasemi
a. A 39-year-old woman had been treated for systemic lupus erythematosus fr
om 1982 to 1993, She was found to have an unexplained increase in serum amy
lase and lipase activities since 1996. Immunoprecipitation assay showed tha
t amylase was bound to IgA2-kappa and IgA1-kappa (IgA2>IgA1), whereas lipas
e was bound to IgA1-kappa, During a follow-up period up to December 1999, t
he patient did not develop any additional autoimmune or lymphoproliferative
disorders. In the situation of atypical clinical features associated with
hyperamylasemia and hyperlipasemia, the possibility of macroenzymes should
be considered.