Objective: This paper reviews the current use of laser techniques for the t
reatment of biliary stones. Background data: Biliary stones may pose a spec
ial problem when access to them is limited, when previous attempts of remov
al have failed, or when a less invasive option than surgery is needed. The
availability of various laser sources and the adaptation of the technology
for safe use in the biliary system make the use of laser energy for stone f
ragmentation possible. Methods: Current literature is reviewed concerning t
he use of laser for biliary lithotripsy, including experimental data and ex
perience with human series. Technology, indications, alternatives, and cumu
lative world experience are discussed. Conclusions: Recent technical advanc
es have made the use of laser energy for fragmentation of biliary calculi p
ossible. It is a valid option for treatment of "difficult" stones, when oth
er methods have failed or as a primary treatment in certain situations. The
technical complexity and the high cost limit its use for specialized cente
rs.