Impaired dentofacial development after radiotherapy of a non-Hodgkin lymphoma: Report of case

Since the advances in therapy of childhood malignancies have improved life expectancy attention is now increasingly focused on the long-term effects o f antineoplastic therapy. Developmental abnormalities due to antineoplastic therapy have been claimed to preferentially occur in children treated befo re the age of six years. This report of a case demonstrates severe developm ental disturbances following radiotherapy of a cervical non-Hodgkin lymphom a at the age of eight years. The morphological changes included microdontia , root shortening, blunting and thinning as well as mandibular hypoplasia.