Successful non-surgical treatment of disseminated polymicrobial fungal infection in a patient with pancytopenia and graft-versus-host disease

Invasive fungal infections after bone marrow transplantation have an extrem ely poor prognosis. Surgical excision in combination with antifungal therap y is considered necessary for treatment, especially for central nervous sys tem (CNS) infection, We describe successful medical management with lipid c omplex amphotericin B (ABLC) and itraconazole, without surgical excision, o f disseminated fungal infection involving the lungs and CNS in a patient wi th pancytopenia and graft-versus-host disease. (C) 2000 The British Infecti on Society.