The synthesis of the alpha(v)beta(3) integrin receptor ligand [I-125]L-775,219.

Authors
Hamill, TG Duggan, ME Perkins, JJ
Citation
Tg. Hamill et al., The synthesis of the alpha(v)beta(3) integrin receptor ligand [I-125]L-775,219., J LABEL C R, 44(1), 2001, pp. 55-59
Citations number
8
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
1
Year of publication
2001
Pages
55 - 59
Database
ISI
SICI code
0362-4803(200101)44:1<55:TSOTAI>2.0.ZU;2-1
Abstract
The alpha (v)beta (3) integrin receptor ligand [I-125]L-775,219, 1c, was sy nthesized for use in an in vitro receptor binding assay with high specific activity (>1500 Ci/mmol) and a radiochemical yield of 15-20%. Conversion of iodide 1b to the corresponding aryl trimethylstannane 2, followed by radio iodination using (NaI)-I-125/iodobead gave 1c.