Radioiodinated alpha(1)-adrenergic receptor ligands

Authors
Hamill, TG Burns, HD Gibson, RE
Citation
Tg. Hamill et al., Radioiodinated alpha(1)-adrenergic receptor ligands, J LABEL C R, 44(1), 2001, pp. 61-72
Citations number
17
Categorie Soggetti
Chemistry & Analysis","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
ISSN journal
03624803 → ACNP
Volume
44
Issue
1
Year of publication
2001
Pages
61 - 72
Database
ISI
SICI code
0362-4803(200101)44:1<61:RARL>2.0.ZU;2-W
Abstract
The synthesis and preliminary characterization of three radioiodinated alph a (1) adrenergic receptor ligands [I-125]5a-c are described. These tracers are analogs of L-760,478, 1b, itself an analog of prazosin, 1a. The highest affinity tracer, [I-125]5a, has six fold higher affinity for the alpha (1) receptor subtypes than prazosin. These ligands could be useful for autorad iographic studies of the alpha (1) receptor subtypes.