The relation between clinical or histologic chorioamnionitis and early neon
atal adverse neurologic outcome was investigated (n = 483). Histologic, but
not clinical, evidence of chorioamnionitis was found to be a significant p
redictor of per;ventricular echodensity (odds ratio, 2.4; 95% CI, 1.8-3.2),
echolucency (3.3; 1.9-5.6), ventriculomegaly (2.7; 1.8-4.2), intraventricu
lar hemorrhage greater than or equal to3 (3.5; 2.4-5.2), and seizures (2.3;
1.4-3.7).