Abundant human beta-defensin-1 expression in milk and mammary gland epithelium

Authors
Jia, HP Starner, T Ackermann, M Kirby, P Tack, BF McCray, PB
Citation
Hp. Jia et al., Abundant human beta-defensin-1 expression in milk and mammary gland epithelium, J PEDIAT, 138(1), 2001, pp. 109-112
Citations number
15
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
JOURNAL OF PEDIATRICS
ISSN journal
00223476 → ACNP
Volume
138
Issue
1
Year of publication
2001
Pages
109 - 112
Database
ISI
SICI code
0022-3476(200101)138:1<109:AHBEIM>2.0.ZU;2-6
Abstract
Human beta -defensin-1 (HBD-1) was detected in breast milk in concentration s of similar to1 to 10 mug/mL. Breast tissue during lactation showed HBD-1 expression in mammary gland epithelia and within luminal secretions. The pe ptide demonstrated antimicrobial activity against Escherichia coli. HBD-1 m ay augment neonatal host defenses through antimicrobial effects or prime th e adaptive immune system at mucosal surfaces.