Atomic force microscopy operated in noncontact mode (NC-AFM) is a promising
method for high-resolution sensing of a wide range of materials regardless
of conductivity. Its feasibility in single-molecule analysis is demonstrat
ed; formate (HCOO-) and acetate (CH3COO-) molecules were identified molecul
e-by-molecule on a TiO2 substrate. The character of the tip-molecule force
responsible for the observed image contrast is discussed.