K. Otani et al., RELATIONSHIP BETWEEN SINGLE ORAL DOSE PHARMACOKINETICS OF ALPRAZOLAM AND TRIAZOLAM, International clinical psychopharmacology, 12(3), 1997, pp. 153-157
The relationship between the single oral dose pharmacokinetics of alpr
azolam and triazolam was studied in 10 healthy male volunteers. Each s
ubject took single oral doses of alprazolam 0.8 mg and triazolam 0.5 m
g with at least a 2 week interval between each dose. Blood samplings w
ere performed up to 48 h after alprazolam dosing and up to 12 h after
triazolam dosing. Plasma concentrations of both drugs were measured by
high-performance liquid chromatography. The means +/- standard deviat
ion of the peak plasma concentration, the total area under the plasma
concentration-time curve and the elimination half-life of alprazolam w
ere 11.3 +/- 3.1 ng/ml, 232.3 +/- 59.2 ng/h/ml and 16.5 +/- 4.6 h, res
pectively, and those of triazolam were 3.2 +/- 1.0 ng/ml, 11.8 +/- 5.2
ng/h/ml and 2.5 +/- 1.1 h, respectively. There was no significant cor
relation between the two drugs in any pharmacokinetic parameters (r =
0.35, 0.25 and 0.50). The present study thus suggests that the single
oral dose pharmacokinetics of alprazolam and triazolam do not correlat
e well in individuals.