Oc. Ilicali et al., Evaluation of the effect of passive smoking on otitis media in children byan objective method: Urinary cotinine analysis, LARYNGOSCOP, 111(1), 2001, pp. 163-167
Objectives: We aimed to determine objectively the effect of the passive smo
king on otitis media with effusion (OME) and recurrent otitis media (ROM) b
y using the method of cotinine urinalysis. Study Design: We designed a pros
pective case control study with follow-up of the case group for 1 year afte
r insertion of tympanostomy tubes to evaluate postoperative complications s
uch as otorrhea and early extrusion (<6 months), in case a significant risk
factor was found. Methods: One hundred fourteen children between 3 and 8 y
ears of age requiring tympanostomy tubes because of OME and ROM were chosen
and compared with 40 age-matched children, Exposure to environmental tobac
co smoke was assessed by cotinine urinalysis, which was performed by means
of the radioimmunoassay method. Results: In this study, 73.7% (84 of 114) o
f the children in the case group and 55.0% (22 of 40) of the children in th
e control group were found to be "exposed" (P = .0461). This difference was
statistically significant. Comparing the cotinine urinalysis results with
parental smoking histories, 23.1% (9 of 39) of the children without parenta
l smoking histories were "exposed" to tobacco smoke versus 84.3% (97 of 115
) of the children with parental smoking histories (at least one person smok
ing). Conclusions: Our results indicate that sidestream smoking increases t
he risk of OME and ROM. Legal regulations and guidelines must be establishe
d to protect children from passive smoking. Because cotinine urinalysis is
a noninvasive and reliable method for the determination of passive smoking,
it can be used for that purpose.