CD5+true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation - Case report and review of the literature

Authors
Evans, HL Polski, JM Deshpande, V Dunphy, CH
Citation
Hl. Evans et al., CD5+true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation - Case report and review of the literature, LEUK LYMPH, 39(5-6), 2000, pp. 625
Citations number
11
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
10428194 → ACNP
Volume
39
Issue
5-6
Year of publication
2000
Database
ISI
SICI code
1042-8194(200011)39:5-6<625:CSWPDA>2.0.ZU;2-#
Abstract
Lymphoplasmacytic lymphoma (LPL) and small lymphocytic lymphoma/chronic lym phocytic leukemia (SLL/CLL)are distinct clinicopathologic entities. Althoug h some cases of SLL/CLL may show plasmacytic differentiation and be associa ted with monoclonal immunoglobulin in serum, such cases appear to be very r are. and if plasma cell differentiation were marked, differentiation of SLL /CLL from LPL could be difficult. We report a rare case of true CDS-positiv e small lymphocytic lymphoma/chronic lymphocytic leukemia with unequivocal plasmacytic differentiation. This case also showed an abnormality of chromo some 1p36 not previously described in small lymphocytic lymphoma/chronic ly mphocytic leukemia.