Myelofibrosis in systemic lupus erythematosus

In this study we present a case of coexisting systemic lupus erythematosus (SLE) and myelofibrosis. Literature review supports the fact that the two d iseases rarely occur together in the same patient. The young female patient studied was admitted with pancytopenia and a clinical picture which met th e criteria of SLE. Histological examination of the bone marrow biopsy revea led severe myelofibrosis with hypocellularity of the myeloid cell lines. Tr eatment with immunosuppressive and colony stimulating factor led to slow bu t complete regeneration of the bone marrow and subsequently to an improved haematological status, and the patient was spared bone marrow transplantati on.