Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells

We vaccinated a refractory essential monoclonal cryoglobulinemia patient wi th monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tum or antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects, Furthermore, cryoglobulin-specific proliferative responses we re observed after the vaccination. As there was a recurrence of acrocyanosi s after the final vaccination. vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.