BIOSYNTHESIS OF 2-C-METHYL-D-ERYTHRITOL, A PUTATIVE C-5 INTERMEDIATE IN THE MEVALONATE INDEPENDENT PATHWAY FOR ISOPRENOID BIOSYNTHESIS

Authors
DUVOLD T BRAVO JM PALEGROSDEMANGE C ROHMER M
Citation
T. Duvold et al., BIOSYNTHESIS OF 2-C-METHYL-D-ERYTHRITOL, A PUTATIVE C-5 INTERMEDIATE IN THE MEVALONATE INDEPENDENT PATHWAY FOR ISOPRENOID BIOSYNTHESIS, Tetrahedron letters, 38(27), 1997, pp. 4769-4772
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
27
Year of publication
1997
Pages
4769 - 4772
Database
ISI
SICI code
0040-4039(1997)38:27<4769:BO2APC>2.0.ZU;2-5
Abstract
According to incorporations of C-13 labelled glucose, 2-C-methyl-D-ery thritol was most likely synthesized by Corynebacterium ammoniagenes fr om glyceraldehyde 3-phosphate and from pyruvate via a condensation and a rearrangement. The observed labelling patterns for methylerythritol were identical with those of the isoprenic units of dihydromenaquinon es from the same bacterium, suggesting for this tetrol an intermediate role in the non-mevalonate pathway for isoprenoid biosynthesis. (C) 1 997 Published by Elsevier Science Ltd.