Cell darwinism, apoptosis, free radicals and haematological malignancies

Authors
Citation
A. Cucuianu, Cell darwinism, apoptosis, free radicals and haematological malignancies, MED HYPOTH, 56(1), 2001, pp. 52-57
Citations number
51
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MEDICAL HYPOTHESES
ISSN journal
03069877 → ACNP
Volume
56
Issue
1
Year of publication
2001
Pages
52 - 57
Database
ISI
SICI code
0306-9877(200101)56:1<52:CDAFRA>2.0.ZU;2-1
Abstract
Haematopoiesis can be interpreted as an ecosystem composed of billions of c ells interacting according to Darwinian rules. Mutation, by promoting cell diversity, ensures versatility in coping with internal and external challen ges. Most mutated cells are eliminated through apoptosis. However, if mutat ion generates relative resistance to apoptosis it may result in growth adva ntage for the mutated cells. The probability of monoclonality and malignanc y is significantly increased if the normal multiclonal environment is damag ed by a pathologic proapoptotic process that spares the apoptosis resistant clones. Paroxysmal nocturnal haemoglobinuria, myelodysplastic syndromes, c hronic myeloid leukaemia, secondary acute leukaemias and immunosuppression- related non-Hodgkin's lymphomas can be interpreted as 'opportunistic' clona l and malignant diseases. Free radicals (FRs) are closely linked to apoptos is and have been incriminated in oncogenesis. Conditions associated with in creased FR formation or impaired FR disposal may provide the enhanced apopt otic background against which an apoptosis-resistant clone may gain growth advantage. (C) 2001 Harcourt Publishers Ltd.