Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment

Objective: We examined the change in menopausal symptoms in response to 24 weeks of isoflavone-rich (80.4 mg/day) and isoflavone-poor (4.4 mg/day) soy protein isolate treatment in perimenopausal women. Design: In this double-blind 24-week study, 69 women were randomized to tre atment: isoflavone-rich soy protein (n = 24), isoflavone-poor soy protein ( n = 24), or whey protein control (n = 21). A Menopausal Index was used to a ssess change in hot flushes and night sweats, as well as other symptoms, at baseline, week 12, and week 24. Results: Repeated measures analysis of variance indicated no treatment effe ct on change in hot flush (17 = 0.18) and night sweat (p = 0.92) frequency, whereas there was a significant decline in hot flush (p = 0.0003) and nigh t sweat (p = 0.0007) frequency with time in all treatment groups. chi (2) a nalyses indicated no treatment effect on severity of hot flushes or night s weats at any time point, as well as no treatment effect on frequency or sev erity of other vasomotor symptoms. At the completion of the study, we found no treatment effect on retrospective perception of frequency, duration, or severity of hot flushes or night sweats. Since time had a significant effe ct on symptoms with all groups reporting a decline in overall symptoms, thi s indicated either a placebo effect or simply an improvement in symptoms du ring the study. Conclusion: In this study, we found no evidence that isoflavone-rich or iso flavone-poor soy protein provided relief of vasomotor or of other menopausa l symptoms.