Symptom reports from a cohort of African American and white women in the late reproductive years

Objective: To identify symptoms experienced in a cohort of healthy women in the late reproductive years; to compare symptom reports between African Am erican and Caucasian women; and to determine the extent to which other Fact ors in reproductive health, mood and behavior, lifestyle, and demographic b ackground are associated with the reported symptoms. Design: A cohort of women aged 35 to 47 years (mean age, 41 years) was iden tified through random digit dialing. This study is a cross-sectional analys is of data collected at enrollment from a subset of 308 women who completed daily symptom reports (DSR) for one menstrual cycle. Data were obtained in structured interviews and self-administered standard questionnaires. The a ssociations of the study variables with symptoms as assessed by the DSR wer e examined using analysis of variance and general linear models. Results: The African American women were significantly more likely to repor t in interview that they experienced menopausal symptoms (46% vs. 30%; p < 0.001) and had significantly higher ratings on the physiological symptom fa ctor of the DSR, which included hot flashes, dizziness, poor coordination/c lumsiness, urine leaks, and vaginal dryness. The DSR yielded two other fact ors of psychological and somatic symptoms. Race was associated only with th e physiological symptom factor in the multivariable analyses. Neither race nor age were associated with psychological symptoms, which were predicted b y current or past mood problems. Conclusions: Symptoms commonly associated with the menopause are experience d in the late reproductive years before observable changes in menstrual cyc les. African American women reported more physiological symptoms than white women. These data provide an essential baseline for longitudinal study of symptoms associated with the ovarian decline in the perimenopausal years.