Hepatitis C virus and interferon resistance

Authors
Taylor, DR Shi, ST Lai, MMC
Citation
Dr. Taylor et al., Hepatitis C virus and interferon resistance, MICROBES IN, 2(14), 2000, pp. 1743-1756
Citations number
150
Categorie Soggetti
Immunology
Journal title
MICROBES AND INFECTION
ISSN journal
12864579 → ACNP
Volume
2
Issue
14
Year of publication
2000
Pages
1743 - 1756
Database
ISI
SICI code
1286-4579(200011)2:14<1743:HCVAIR>2.0.ZU;2-A
Abstract
Interferon plays a critical role in the host's natural defense against vira l infections and in their treatment. It is the only therapy for hepatitis C virus (HCV) infection; however, many virus isolates are resistant. Several HCV proteins have been shown to possess properties that enable the virus t o evade the interferon-mediated cellular antiviral responses. (C) 2000 Edit ions scientifiques et medicales Elsevier SAS.