The significance of cytomegalovirus infection over the clinical course of adult T-cell leukemia/lymphoma

Authors
Fujiwara, H Eizuru, Y Matsumoto, T Kukita, T Imaizumi, R Kawada, H Ohtsubo, H Matsushita, K Arima, N Tei, C
Citation
H. Fujiwara et al., The significance of cytomegalovirus infection over the clinical course of adult T-cell leukemia/lymphoma, MICROB IMMU, 45(1), 2001, pp. 97-100
Citations number
17
Categorie Soggetti
Microbiology
Journal title
MICROBIOLOGY AND IMMUNOLOGY
ISSN journal
03855600 → ACNP
Volume
45
Issue
1
Year of publication
2001
Pages
97 - 100
Database
ISI
SICI code
0385-5600(2001)45:1<97:TSOCIO>2.0.ZU;2-F
Abstract
The significance of cytomegalovirus (CMV) infections developed over the cli nical course of adult T-cell leukemia/lymphoma (ATLL) were evaluated in rel ation to the patient survival rate, ATL activity and immunocompetent cells. ATLL patients with CMV infections on admission exhibited a poor survival r ate, while patients with CMV infections at any time after admission survive d longer than those not infected with this virus. ATLL patients who exhibit ed a numbers of CMV infection on admission showed higher ATL activity and h ad lower numbers of CDS-positive and CD56-positive cells than those who dev eloped CMV infections at any time after admission. Therefore, it appears li kely that patients with CMV infections on admission were in an immunosuppre ssive state due to aggressive ATL activity.