Pj. Kenny et al., Acute nicotine decreases, and chronic nicotine increases the expression ofbrain-derived neurotrophic factor mRNA in rat hippocampus, MOL BRAIN R, 85(1-2), 2000, pp. 234-238
Acute nicotine administration (0.5 mg/kg i.p.) significantly decreased BDNF
mRNA levels in dentate gyrus, CA3 and CA1 subfields of the rat hippocampus
2 h and 24 h after administration. However, with 7 days nicotine treatment
, tolerance developed to the inhibitory effect of nicotine on BDNF mRNA exp
ression and there was a significant increase in BDNF expression 2 h after t
he final injection in the CA1 region. These data suggests that changes in e
xpression of hippocampal BDNF may be involved in the behavioural effects of
nicotine observed after acute and chronic treatment. (C) 2000 Elsevier Sci
ence B.V. All rights reserved.