Acute nicotine decreases, and chronic nicotine increases the expression ofbrain-derived neurotrophic factor mRNA in rat hippocampus

Authors
Kenny, PJ File, SE Rattray, M
Citation
Pj. Kenny et al., Acute nicotine decreases, and chronic nicotine increases the expression ofbrain-derived neurotrophic factor mRNA in rat hippocampus, MOL BRAIN R, 85(1-2), 2000, pp. 234-238
Citations number
29
Categorie Soggetti
Neurosciences & Behavoir
Journal title
MOLECULAR BRAIN RESEARCH
ISSN journal
0169328X → ACNP
Volume
85
Issue
1-2
Year of publication
2000
Pages
234 - 238
Database
ISI
SICI code
0169-328X(200012)85:1-2<234:ANDACN>2.0.ZU;2-1
Abstract
Acute nicotine administration (0.5 mg/kg i.p.) significantly decreased BDNF mRNA levels in dentate gyrus, CA3 and CA1 subfields of the rat hippocampus 2 h and 24 h after administration. However, with 7 days nicotine treatment , tolerance developed to the inhibitory effect of nicotine on BDNF mRNA exp ression and there was a significant increase in BDNF expression 2 h after t he final injection in the CA1 region. These data suggests that changes in e xpression of hippocampal BDNF may be involved in the behavioural effects of nicotine observed after acute and chronic treatment. (C) 2000 Elsevier Sci ence B.V. All rights reserved.