Postictal stability of proton magnetic resonance spectroscopy imaging (H-1-MRSI) ratios in temporal lobe epilepsy

Interictal proton (H-1) MRS is increasingly used for seizure lateralization in patients with temporal lobe epilepsy (TLE). Studies reporting postictal H-1-MRS metabolite changes in patients with TLE are few and contradictory. The authors prospectively performed interictal and postictal proton magnet ic resonance spectroscopy imaging (H-1-MRSI) studies in seven patients with TLE. The authors found no consistent changes in metabolite peak area ratio s between studies, suggesting that H-1-MRS ratios remain stable between int erictal and postictal state in TLE.