Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse

Here we describe the expression of a third member of the VPS10 domain conta ining receptor family, SorCS, during mouse embryonal and early postnatal ne rvous system development. SorCS is expressed in a unique transient and dyna mic pattern in regions where cells proliferate, as well as in areas where a lready differentiated cells reside, including the cerebral cortex, the vent ral tegmental area, and the globus pallidus. Transcripts were absent from f iber tracts hinting at a neuronal expression. The only exception was hybrid ization signals on the developing optic nerve correlating with the appearan ce of astrocytes migrating into the retina. NeuroReport 12:29-32 (C) 2001 L ippincott Williams & Wilkins.