Equivalent disruption of regional white matter microstructure in ageing healthy men and women

Diffusion tensor imaging was used to measure regional differences in brain white matter microstructure (intravoxel coherence) and macrostructure (inte rvoxel coherence) and age-related differences between men and women. Neurop sychiatrically healthy men and women. spanning the adult age range, showed the same pattern of variation in regional white matter coherence. The great est coherence measured was in corpus callosum, where commissural fibers hav e one primary orientation, lower in the centrum semiovale, where fibers cro ss from multiple axes, and lowest in pericallosal areas, where fibers weave and interstitial fluid commonly pools. Age-related declines in intravoxel coherence was equally strong and strikingly similar in men and women, with evidence for greater age-dependent deterioration in frontal than parietal r egions. Degree of regional white matter coherence correlated with gait, bal ance, and interhemispheric transfer test scores. NeuroReport 12:99-104 (C) 2001 Lippincott Williams & Wilkins.