The SBASE protein domain library, release 8.0: a collection of annotated protein sequence segments

SBASE 8.0 is the eighth release of the SBASE library of protein domain sequ ences that contains 294 898 annotated structural, functional, ligand-bindin g and topogenic segments of proteins, cross-referenced to most major sequen ce databases and sequence pattern collections. The entries are clustered in to over 2005 statistically validated domain groups (SBASE-A) and 595 non-va lidated groups (SBASE-B), provided with several WWW-based search and browsi ng facilities for online use. A domain-search facility was developed, based on non-parametric pattern recognition methods, including artificial neural networks. SBASE 8.0 is freely available by anonymous 'ftp' file transfer f rom ftp.icgeb.trieste.it. Automated searching of SBASE can be carried out w ith the WWW servers http://www.icgeb.trieste.it/ sbase/ and http://sbase.ab c.hu/sbase/.