YPD (TM), PombePD (TM) and WormPD (TM): model organism volumes of the BioKnowledge (TM) Library, an integrated resource for protein information

The BioKnowledge Library is a relational database and web site (http:www.pr oteome.com) composed of protein-specific information collected from the sci entific literature. Each Protein Report on the web site summarizes and disp lays published information about a single protein, including its biochemica l function, role in the cell and in the whole organism, localization, mutan t phenotype and genetic interactions, regulation, domains and motifs, inter actions with other proteins and other relevant data. This report describes four species-specific volumes of the BioKnowledge Library, concerned with t he model organisms Saccharomyces cerevisiae (YPD), Schizosaccharomyces pomb e (PombePD) and Caenorhabditis elegans (WormPD), and with the fungal pathog en Candida albicans (CalPD(TM)). Protein Reports of each species are unifie d in format, easily searchable and extensively cross-referenced between spe cies. The relevance of these comprehensively curated resources to analysis of proteins in other species is discussed, and is illustrated by a survey o f model organism proteins that have similarity to human proteins involved i n disease.