NTDB: Thermodynamic Database for Nucleic Acids

A new thermodynamic database for normal and modified nucleic acids has been developed. This Thermodynamic Database for Nucleic Acids (NTDB) includes s equence, structure and thermodynamic information as well as experimental me thods and conditions. In this release, there are 1851 sequences containing both normal and modified nucleic acids. A user-friendly web-based interface has been developed to allow data searching under different conditions. Use ful thermodynamic tools for the study of nucleic acids have been collected and linked for easy usage. NTDB is available at http:// ntdb.chem.cuhk.edu. hk.