ACTIVITY: a database on DNA/RNA sites activity adapted to apply sequence-activity relationships from one system to another

ACTIVITY is a database on DNA/RNA site sequences with known activity magnit udes, measurement systems, sequence-activity relationships under fixed expe rimental conditions and procedures to adapt these relationships from one me asurement system to another, This database deposits information on DNA/RNA affinities-to proteins and cell nuclear extracts, cutting efficiencies, gen e transcription activity, mRNA translation efficiencies, mutability and oth er biological activities of natural sites occurring within promoters, mRNA leaders, and other regulatory regions in pro- and eukaryotic genomes, their mutant forms and synthetic analogues. Since activity magnitudes are heavil y system-dependent, the current version of ACTIVITY is supplemented by thre e novel sub-databases: (i) SYSTEM, measurement systems; (ii) KNOWLEDGE, seq uence-activity relationships under fixed experimental conditions; and (iii) CROSS_TEST, procedures adapting a relationship from one measurement system to another. These databases are useful in molecular biology, pharmacogenet ics, metabolic engineering, drug design and biotechnology, The databases ca n be queried using SRS and are available through the Web, http ://wwwmgs.bi onet.nsc.ru/ systems/Activity/.