Human Immunodeficiency Virus Reverse Transcriptase and Protease Sequence Database: an expanded data model integrating natural language text and sequence analysis programs

The HIV Reverse Transcriptase and Protease Sequence Database is an on-line relational database that catalogs evolutionary and drug-related sequence va riation in the human immunodeficiency virus (HIV) reverse transcriptase (RT ) and protease enzymes, the molecular targets of anti-HIV therapy (http://h ivdb.stanford.edu). The database contains a compilation of nearly all publi shed HIV RT and protease sequences, including submissions from internationa l Collaboration databases and sequences published in journal articles. Sequ ences are linked to data about the source of the sequence sample and the an tiretroviral drug treatment history of the individual from whom the isolate was obtained. During the past year 3500 sequences have been added and the data model has been expanded to include drug susceptibility data on sequenc ed isolates. Database content has also been integrated with didactic text a nd the output of two sequence analysis programs.