Jv. Ponomarenko et al., rSNP_Guide, a database system for analysis of transcription factor bindingto target sequences: application to SNPs and site-directed mutations, NUCL ACID R, 29(1), 2001, pp. 312-316
rSNP_Guide is a novel curated database system for analysis of transcription
factor (TF) binding to target sequences in regulatory gene regions altered
by mutations. It accumulates experimental data on naturally occurring site
variants in regulatory gene regions and site-directed mutations. This data
base system also contains the web tools for SNP analysis, i.e,, active appl
et applying weight matrices to predict the regulatory site candidates alter
ed by a mutation. The current version of the rSNP_Guide is supplemented by
six sub-databases: (i) rSNP_DB, on DNA-protein interaction caused by mutati
on; (ii) SYSTEM, on experimental systems; (iii) rSNP_BIB, on citations to o
riginal publications; (iv) SAMPLES, on experimentally identified sequences
of known regulatory sites; (v) MATRIX, on weight matrices of known TF sites
; (vi) rSNP_Report, on characteristic examples of successful rSNP_Tools imp
lementation. These databases are useful for the analysis of natural SNPs an
d site-directed mutations. The databases are available through the Web, htt
p://wwwmgs.bionet.nsc.ru/mgs/ systems/rsnp/.