A definite relationship is emerging between periodontal infections and syst
emic conditions. The objective of this review is to address this relationsh
ip as it pertains to cardiovascular disease and diabetes mellitus. Furtherm
ore, because recent reports link the presence of periodontal disease to pre
term delivery, the possible relationship between the development and progre
ssion of periodontal disease and certain hormonal states in women such as p
uberty, oral contraceptive use, menopause, and pregnancy will also be discu
ssed. Although the current literature suggests a strong association between
periodontal disease and a number of the discussed systemic conditions, cau
sality can only be established with prospective studies. Intervention studi
es are needed to address how treatment effects the incidence and/or severit
y of periodontal disease-related systemic illness.