The copper-mediated cross coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: Synthesis of aryloxyamines

Authors
Petrassi, HM Sharpless, KB Kelly, JW
Citation
Hm. Petrassi et al., The copper-mediated cross coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: Synthesis of aryloxyamines, ORG LETT, 3(1), 2001, pp. 139-142
Citations number
20
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
1
Year of publication
2001
Pages
139 - 142
Database
ISI
SICI code
1523-7060(20010111)3:1<139:TCCCOP>2.0.ZU;2-C
Abstract
[GRAPHICS] A novel route to aryloxyamines via the copper mediated cross-coupling of N- hydroxyphthalimide and phenylboronic acids is reported. The reaction is med iated by selected copper(I) and (II) salts in the presence of pyridine and is tolerant of several functional groups on the phenylboronic acid. The pht halimide group is removed using hydrazine to afford the corresponding arylo xyamine.