W. Pakulska et E. Czarnecka, Effect of diazepam and midazolam on the antinociceptive effect of morphine, metamizol and indomethacin in mice, PHARMAZIE, 56(1), 2001, pp. 89-91
The influence of midazolam and diazepam on antinociceptive effect of morphi
ne (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg) was invest
igated in a mouse model using the tail-flick and hot-plate tests. All drugs
were injected intraperitoneally. Benzodiazepines were administered to mice
30 min before applying the analgesic drugs. Measurement of nociception was
performed within 2 h after benzodiazepine administration. Diazepam at dose
s of 0.25 mg/kg and 2.5 mg/kg injected with morphine was found to decrease
the antinociceptive effect of morphine. Similarly, diazepam decreased the a
ntinociceptive effect of metamizol (only in the tail-flick test) and indome
thacin. Midazolam used at doses of 1.25 mg/kg and 2.5 mg/kg decreased the a
ntinociceptive effect of morphine, metamizol (only in the tail-flick test)
and indomethacin.