The trehalose operon of Pseudomonas fluorescens ATCC 17400 consists of treP
, treA and treR. The gene treP codes for a putative enzyme II subunit of th
e phosphotransferase system that catalyzes the phosphorylation of trehalose
together with its translocation across the cell membrane and treA encodes
a putative phosphotrehalase, which hydrolyzes the incoming trehalose-6-phos
phate into glucose and glucose-6-phosphate. Both genes are negatively regul
ated by TreR, a repressor of the FadR-GntR family of transcription regulato
rs. The operon that is induced by trehalose present in the medium shows a h
igh similarity both in the function of genes and in the regulation with the
trehalose operon of Bacillus subtilis. (C) 2000 Editions scientifiques et
medicales Elsevier SAS.